Patient-Centred Pharmaceutical Design to Improve Acceptability of Medicines: Similarities and Differences in Paediatric and Geriatric Populations
Identifieur interne : 001831 ( Main/Exploration ); précédent : 001830; suivant : 001832Patient-Centred Pharmaceutical Design to Improve Acceptability of Medicines: Similarities and Differences in Paediatric and Geriatric Populations
Auteurs : Fang Liu ; Sejal Ranmal [Royaume-Uni] ; Hannah K. Batchelor [Royaume-Uni] ; Mine Orlu-Gul [Royaume-Uni] ; Terry B. Ernest ; Iwan W. Thomas ; Talia Flanagan ; Catherine Tuleu [Royaume-Uni]Source :
- Drugs [ 0012-6667 ] ; 2014.
Abstract
Patient acceptability of a medicinal product is a key aspect in the development and prescribing of medicines. Children and older adults differ in many aspects from the other age subsets of population and require particular considerations in medication acceptability. This review highlights the similarities and differences in these two age groups in relation to factors affecting acceptability of medicines. New and conventional formulations of medicines are considered regarding their appropriateness for use in children and older people. Aspects of a formulation that impact acceptability in these patient groups are discussed, including, for example, taste/smell/viscosity of a liquid and size/shape of a tablet. A better understanding of the acceptability of existing formulations highlights opportunities for the development of new and more acceptable medicines and facilitates safe and effective prescribing for the young and older populations.
The online version of this article (doi:10.1007/s40265-014-0297-2) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s40265-014-0297-2
PubMed: 25274536
PubMed Central: 4210646
Affiliations:
- Royaume-Uni
- Angleterre, Grand Londres, Midlands de l'Ouest
- Birmingham, Londres
- University College de Londres, Université de Birmingham
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Batchelor</name><affiliation wicri:level="4"><nlm:aff id="Aff3">Pharmacy, Pharmacology and Therapeutics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT UK</nlm:aff><orgName type="university">Université de Birmingham</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Orlu Gul, Mine" sort="Orlu Gul, Mine" uniqKey="Orlu Gul M" first="Mine" last="Orlu-Gul">Mine Orlu-Gul</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX UK</nlm:aff><orgName type="university">University College de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ernest, Terry B" sort="Ernest, Terry B" uniqKey="Ernest T" first="Terry B." last="Ernest">Terry B. 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Thomas</name><affiliation><nlm:aff id="Aff5">Piramal Healthcare UK Ltd, Morpeth, Northumberland NE61 3YA UK</nlm:aff><wicri:noCountry code="subfield">Northumberland NE61 3YA UK</wicri:noCountry></affiliation></author><author><name sortKey="Flanagan, Talia" sort="Flanagan, Talia" uniqKey="Flanagan T" first="Talia" last="Flanagan">Talia Flanagan</name><affiliation><nlm:aff id="Aff6">Pharmaceutical Development, AstraZeneca, Macclesfield, Cheshire SK10 2NA UK</nlm:aff><wicri:noCountry code="subfield">Cheshire SK10 2NA UK</wicri:noCountry></affiliation></author><author><name sortKey="Tuleu, Catherine" sort="Tuleu, Catherine" uniqKey="Tuleu C" first="Catherine" last="Tuleu">Catherine Tuleu</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX UK</nlm:aff><orgName type="university">University College de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Drugs</title><idno type="ISSN">0012-6667</idno><idno type="eISSN">1179-1950</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Patient acceptability of a medicinal product is a key aspect in the development and prescribing of medicines. Children and older adults differ in many aspects from the other age subsets of population and require particular considerations in medication acceptability. This review highlights the similarities and differences in these two age groups in relation to factors affecting acceptability of medicines. New and conventional formulations of medicines are considered regarding their appropriateness for use in children and older people. Aspects of a formulation that impact acceptability in these patient groups are discussed, including, for example, taste/smell/viscosity of a liquid and size/shape of a tablet. A better understanding of the acceptability of existing formulations highlights opportunities for the development of new and more acceptable medicines and facilitates safe and effective prescribing for the young and older populations.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1007/s40265-014-0297-2) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kozarewicz, P" uniqKey="Kozarewicz P">P Kozarewicz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paradiso, Lm" uniqKey="Paradiso L">LM Paradiso</name></author><author><name sortKey="Roughead, Ee" uniqKey="Roughead E">EE Roughead</name></author><author><name sortKey="Gilbert, Al" uniqKey="Gilbert A">AL Gilbert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cuzzolin, L" 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sortKey="Ntawukulilyayo, Jd" uniqKey="Ntawukulilyayo J">JD Ntawukulilyayo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Midlands de l'Ouest</li></region><settlement><li>Birmingham</li><li>Londres</li></settlement><orgName><li>University College de Londres</li><li>Université de Birmingham</li></orgName></list><tree><noCountry><name sortKey="Ernest, Terry B" sort="Ernest, Terry B" uniqKey="Ernest T" first="Terry B." last="Ernest">Terry B. Ernest</name><name sortKey="Flanagan, Talia" sort="Flanagan, Talia" uniqKey="Flanagan T" first="Talia" last="Flanagan">Talia Flanagan</name><name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name><name sortKey="Thomas, Iwan W" sort="Thomas, Iwan W" uniqKey="Thomas I" first="Iwan W." last="Thomas">Iwan W. Thomas</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ranmal, Sejal" sort="Ranmal, Sejal" uniqKey="Ranmal S" first="Sejal" last="Ranmal">Sejal Ranmal</name></region><name sortKey="Batchelor, Hannah K" sort="Batchelor, Hannah K" uniqKey="Batchelor H" first="Hannah K." last="Batchelor">Hannah K. Batchelor</name><name sortKey="Orlu Gul, Mine" sort="Orlu Gul, Mine" uniqKey="Orlu Gul M" first="Mine" last="Orlu-Gul">Mine Orlu-Gul</name><name sortKey="Tuleu, Catherine" sort="Tuleu, Catherine" uniqKey="Tuleu C" first="Catherine" last="Tuleu">Catherine Tuleu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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